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Number of shares issued for each share of convertible preferred stock that is converted.

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Gain (loss) related to the termination of a contract between the parties. The termination may be due to many causes including early termination of a lease by a lessee, a breach of contract by one party, or a failure to perform.

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Describe the conversion features of preferred stock if preferred stock is convertible. That is, shares of preferred stock into which another convertible security was converted, or shares of preferred stock into which another class of preferred stock was converted.

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The cash inflow from the additional capital contribution to the entity.

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Per share amount received by subsidiary or equity investee for each share of common stock issued or sold in the stock transaction.

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Number of new stock issued during the period.

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Collaborative development and license agreement termination date.

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Maximum beneficial ownership limitation percentage for conversion of common stock issued and outstanding.

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Maximum beneficial ownership limitation upon notice, percentage for conversion of common stock issued and outstanding.

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Maximum beneficial percentage hold for conversion of number Of common stock issued and outstanding.

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Minimum beneficial percentage hold for conversion of number of common stock issued and outstanding.

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Number of common shares agreed to transfer and assign for cancellation.

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Share capital.

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Share Capital (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended				3 Months Ended		9 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jul. 31, 2018	May 31, 2018	Mar. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Sep. 30, 2018	Sep. 09, 2019
Share Capital [Line Items]
Sale proceeds of common shares								$ 102,842
Gain on termination of collaboration agreement					$ 4,398			$ 4,398
Inducement Plan [Member]
Share Capital [Line Items]
Common shares reserved for issuance									400,000
Series1 Preferred Shares
Share Capital [Line Items]
Conversion of shares	1,852,000
Common Shares [Member]
Share Capital [Line Items]
Conversion of shares	1,852,000
BVF Partners L.P [Member] \| Exchange Agreement [Member]
Share Capital [Line Items]
Estimated weighted average cancellation price per share of common stock					$ 7.61
BVF Partners L.P [Member] \| Exchange Agreement [Member] \| Series1 Preferred Shares
Share Capital [Line Items]
Shares issued					2,868,000
Preferred shares convertible into common shares					one-for-one
Common shares issued on conversion of preferred stock					1
Maximum beneficial ownership limitation percentage for conversion of common stock issued and outstanding					9.99%
Maximum beneficial ownership limitation upon notice, percentage for conversion of common stock issued and outstanding					19.99%
Maximum beneficial percentage hold for conversion of number Of common stock issued and outstanding					5.00%
Minimum beneficial percentage hold for conversion of number Of common stock issued and outstanding.					5.00%
BVF Partners L.P [Member] \| Exchange Agreement [Member] \| Common Shares [Member]
Share Capital [Line Items]
Shares issued					2,868,000
Common Shares [Member]
Share Capital [Line Items]
Shares issued						6,100,000	3,440,000
Conversion of shares						1,300,000
Stifel [Member] \| At-The-Market Equity Offering [Member]
Share Capital [Line Items]
Sale proceeds of common shares				$ 29,200
Stifel [Member] \| At-The-Market Equity Offering [Member] \| Maximum [Member]
Share Capital [Line Items]
Sale proceeds of common shares				$ 30,000
Stifel [Member] \| At-The-Market Equity Offering [Member] \| Common Shares [Member]
Share Capital [Line Items]
Shares issued				3,440,000
Jefferies and Stifel [Member] \| At-The-Market Equity Offering Sales Agreement [Member]
Share Capital [Line Items]
Sale proceeds of common shares			$ 14,820
Jefferies and Stifel [Member] \| Maximum [Member] \| At-The-Market Equity Offering Sales Agreement [Member]
Share Capital [Line Items]
Sale proceeds of common shares			$ 50,000
Jefferies and Stifel [Member] \| Common Shares [Member] \| At-The-Market Equity Offering Sales Agreement [Member]
Share Capital [Line Items]
Shares issued			1,600,000
Jefferies and Stifel [Member] \| Underwritten Public Offering [Member]
Share Capital [Line Items]
Sale proceeds of common shares		$ 59,220
Jefferies and Stifel [Member] \| Underwritten Public Offering [Member] \| Common Shares [Member]
Share Capital [Line Items]
Shares issued		4,500,000
Shares price		$ 14.00				$ 14.00		$ 14.00
Teva [Member]
Share Capital [Line Items]
Collaborative development and license agreement termination date					Mar. 31, 2018
Teva Canada Limited [Member]
Share Capital [Line Items]
Number of common shares transferred and assigned for cancellation					1,000,000