Consolidated Statements of Shareholders' Equity (Unaudited) - USD ($) $ in Thousands	Total		Convertible Preferred Shares [Member]	Common Shares [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Loss [Member]	[1]
Balance at Dec. 31, 2017	$ 35,934			$ 173,841	$ 36,471	$ (173,388)	$ (990)
Balance (in Shares) at Dec. 31, 2017				17,998,420
Net loss	(3,755)					(3,755)
Issued (cancelled) pursuant to exchange agreement (note 9b)			$ 21,825	$ (21,825)
Issued (cancelled) pursuant to exchange agreement (note 9b) (in Shares)			2,868,000	(2,868,000)
Cancelled pursuant to termination of collaboration agreement (note 9c)	(4,470)			$ (4,470)
Cancelled pursuant to termination of collaboration agreement (note 9c) (in Shares)				(1,000,000)
Stock-based compensation expense	670				670
Issued pursuant to exercise of stock options	$ 119			$ 341	(222)
Issued pursuant to exercise of of stock options (in Shares)	84,668	[2]		40,881
Balance at Mar. 31, 2018	$ 28,498		$ 21,825	$ 147,887	36,919	(177,143)	(990)
Balance (in Shares) at Mar. 31, 2018			2,868,000	14,171,301
Balance at Dec. 31, 2018	103,295		$ 7,732	$ 265,923	38,515	(207,885)	(990)
Balance (in Shares) at Dec. 31, 2018			1,016,000	25,750,721
Cumulative effect of accounting change	(175)					(175)
Net loss	(11,341)					(11,341)
Stock-based compensation expense	476				476
Issued pursuant to exercise of stock options	$ 58			$ 117	(59)
Issued pursuant to exercise of of stock options (in Shares)	22,402	[2]		21,233
Balance at Mar. 31, 2019	$ 92,313		$ 7,732	$ 266,040	$ 38,932	$ (219,401)	$ (990)
Balance (in Shares) at Mar. 31, 2019			1,016,000	25,771,954

[1] Our accumulated other comprehensive loss is entirely related to historical cumulative translation adjustments from the application of U.S. dollar reporting when the functional currency of the Company was the Canadian dollar.

[2] During the three months ended March 31, 2019, 20,576 stock options were exercised for the same number of common shares for cash (three months ended March 31, 2018 – 13,374). In the same period, the Company issued 657 common shares (three months ended March 31, 2018 – 27,507) for the cashless exercise of 1,826 stock options (three months ended March 31, 2018 – 71,294).