Consolidated Statement of Shareholders' Equity (Unaudited) - USD ($) $ in Thousands		Total	Convertible Preferred Shares [Member]	Common Shares [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Loss [Member]	[1]
Balance at Dec. 31, 2016		$ 63,901		$ 173,246	$ 34,326	$ (142,681)	$ (990)
Balance (in Shares) at Dec. 31, 2016				17,930,590
Net loss		(30,704)				(30,704)
Stock-based compensation expense		2,460			2,460
Issued pursuant to exercise of stock options		177		$ 595	(415)	(3)
Issued pursuant to exercise of stock options (in Shares)				67,830
Issuance of warrants		100			100
Balance at Dec. 31, 2017		35,934		$ 173,841	36,471	(173,388)	(990)
Balance (in Shares) at Dec. 31, 2017				17,998,420
Net loss		(25,939)				(25,939)
Issuance of common shares,net of issuance costs (note 9a)		102,842		$ 102,842
Issuance of common shares, net of issuance costs (note 9a) (in shares)				9,540,000
Issued (cancelled) pursuant to exchange agreement (note 9b)			$ 21,825	$ (21,825)
Issued (cancelled) pursuant to exchange agreement (note 9b) (in Shares)			2,868,000	(2,868,000)
Conversion of preferred shares to common shares (note 9b)			$ (9,893)	$ 9,893
Conversion of preferred shares to common shares (note 9b) (in shares)			(1,300,000)	1,300,000
Cancelled pursuant to termination of collaboration agreement (note 9c)		(4,470)		$ (4,470)
Cancelled pursuant to termination of collaboration agreement (note 9c) (in Shares)				(1,000,000)
Stock-based compensation expense		$ 1,989			1,989
Issued pursuant to exercise of stock options (in Shares)	[2]	237,848
Issued pursuant to exercise of stock options and warrants		$ 262		$ 1,374	(1,112)
Issued pursuant to exercise of stock options and warrants (in shares)				217,021
Issuance of warrants		538			538
Balance at Sep. 30, 2018		$ 111,156	$ 11,932	$ 261,655	$ 37,886	$ (199,327)	$ (990)
Balance (in Shares) at Sep. 30, 2018			1,568,000	25,187,441

[1] Our accumulated other comprehensive loss is entirely related to historical cumulative translation adjustments from the application of U.S. dollar reporting when the functional currency of the Company was the Canadian dollar.

[2] During the nine months ended September 30, 2018, 41,507 stock options were exercised for the same number of common shares for cash (nine months ended September 30, 2017 – 63,425). In the same period, the Company issued 103,189 common shares (nine months ended September 30, 2017 – 4,405) for the cashless exercise of 196,341 stock options (nine months ended September 30, 2017 – 7,581).