Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenue:
Collaboration revenue		$ 16
Operating expenses:
Research and development	$ 5,580	5,903
General and administrative	2,238	2,100
Total operating expenses	7,818	8,003
Loss from operations	(7,818)	(7,987)
Other income (expense):
Interest income	108	149
Interest expense	(159)
Foreign exchange gain (loss)	(284)	321
Gain on termination of collaboration agreement (note 9b)	4,398
Net loss and comprehensive loss	(3,755)	(7,517)
Net loss attributable to preferred shareholders	(33)
Net loss attributable to common shareholders	$ (3,722)	$ (7,517)
Net loss per common share (note 5):
Basic	$ (0.21)	$ (0.42)
Diluted	$ (0.21)	$ (0.43)
Weighted-average common shares outstanding (note 5):
Basic	17,804,421	17,946,209
Diluted	17,804,421	17,974,469