XML 71 R56.htm IDEA: XBRL DOCUMENT v3.8.0.1
Commitments and Contingencies (Details)
$ in Thousands
1 Months Ended 12 Months Ended
Jul. 31, 2017
USD ($)
Apr. 30, 2017
USD ($)
Mar. 31, 2017
CAD
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Aug. 31, 2015
USD ($)
Commitments and Contingencies [Line Items]              
Lease Agreement Description       for a 120-month term from April 1, 2012 to March 31, 2022,      
Lease Expiration Date       Mar. 31, 2022      
Amended Operating Leases Term       120 months      
Operating Leases, Rent Expense       $ 1,079 $ 936 $ 917  
Prepaid expenses, long term       230 408    
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. [Member]              
Commitments and Contingencies [Line Items]              
Upfront fee paid   $ 350          
Milestone payments paid       $ 700      
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Clinical Development Milestones [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments   1,000          
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Regulatory Milestone [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments   13,000          
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Sales-based and Other Milestones [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments   33,600          
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Pre-commercial and Single Digit Percentage Royalty on Commercial Sales Milestone [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments   $ 1,500          
License Agreement [Member]              
Commitments and Contingencies [Line Items]              
Upfront fee paid $ 1,000            
License Agreement [Member] | Clinical Development Milestones [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments 2,000            
License Agreement [Member] | Regulatory Milestone [Member] | Maximum [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments $ 7,000            
Medpace Clinical Development Service Agreement [Member]              
Commitments and Contingencies [Line Items]              
Service agreement, term       5 years      
Committed service obligation             $ 7,000
Contractual obligation paid           $ 3,000  
Expenses for services rendered       $ 2,770      
Current prepaid expenses       392    
Prepaid expenses, long term       $ 230 $ 408    
License, Manufacture and Supply Agreement [Member]              
Commitments and Contingencies [Line Items]              
Upfront fee paid | CAD     CAD 500