Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenue:
Collaboration revenue (note 8)	$ 264	$ 412	$ 294	$ 1,393
Royalties		1	1	34
Revenues	264	413	295	1,427
Operating expenses:
Research and development	7,164	5,965	19,176	15,432
General and administrative	1,744	1,779	5,643	5,350
Total operating expenses	8,908	7,744	24,819	20,782
Loss from operations	(8,644)	(7,331)	(24,524)	(19,355)
Other income:
Interest income	124	114	382	336
Foreign exchange gain (loss)	778	(497)	1,503	2,026
Net loss and comprehensive loss	$ (7,742)	$ (7,714)	$ (22,639)	$ (16,993)
Net loss per common share (note 4):
Basic	$ (0.43)	$ (0.51)	$ (1.26)	$ (1.16)
Diluted	$ (0.43)	$ (0.51)	$ (1.27)	$ (1.16)
Weighted-average common shares outstanding (note 4):
Basic	17,998,420	15,268,964	17,980,608	14,690,357
Diluted	18,009,979	15,268,964	18,000,066	14,690,357