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Commitments and Contingencies (Details)
$ in Thousands
1 Months Ended 9 Months Ended 12 Months Ended
Jul. 31, 2017
USD ($)
Apr. 30, 2017
USD ($)
Mar. 31, 2017
CAD
Sep. 30, 2017
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Aug. 31, 2015
USD ($)
Commitments and Contingencies [Line Items]                
Prepaid expenses, long term       $ 218     $ 408  
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. [Member]                
Commitments and Contingencies [Line Items]                
Upfront fee paid   $ 350            
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. [Member] | Scenario, Forecast [Member]                
Commitments and Contingencies [Line Items]                
Expects to pay an additional milestone payment           $ 700    
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Clinical Development Milestones [Member]                
Commitments and Contingencies [Line Items]                
Future potential payments   1,000            
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Regulatory Milestone [Member]                
Commitments and Contingencies [Line Items]                
Future potential payments   13,000            
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Sales-based and Other Milestones [Member]                
Commitments and Contingencies [Line Items]                
Future potential payments   33,600            
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Pre-commercial and Single Digit Percentage Royalty on Commercial Sales Milestone [Member]                
Commitments and Contingencies [Line Items]                
Future potential payments   $ 1,500            
License Agreement [Member]                
Commitments and Contingencies [Line Items]                
Upfront fee paid $ 1,000              
License Agreement [Member] | Clinical Development Milestones [Member]                
Commitments and Contingencies [Line Items]                
Future potential payments 2,000              
License Agreement [Member] | Regulatory Milestone [Member] | Maximum [Member]                
Commitments and Contingencies [Line Items]                
Future potential payments 7,000              
License Agreement [Member] | Single-Digit Percentage Royalty on Net Sales [Member]                
Commitments and Contingencies [Line Items]                
Future potential payments $ 1,000              
Medpace Clinical Development Service Agreement [Member]                
Commitments and Contingencies [Line Items]                
Service agreement, term       5 years        
Committed service obligation               $ 7,000
Contractual obligation paid         $ 3,000      
Expenses for services rendered       $ 2,714        
Current prepaid expenses       68     392  
Prepaid expenses, long term       $ 218     $ 408  
License, Manufacture and Supply Agreement [Member]                
Commitments and Contingencies [Line Items]                
Upfront fee paid | CAD     CAD 500