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Commitments and Contingencies (Details)
$ in Thousands
1 Months Ended 6 Months Ended 12 Months Ended
Apr. 30, 2017
USD ($)
Mar. 31, 2017
CAD
Jun. 30, 2017
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Aug. 31, 2015
USD ($)
Commitments and Contingencies [Line Items]              
Prepaid expenses, long term     $ 285     $ 408  
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. [Member]              
Commitments and Contingencies [Line Items]              
Upfront fee paid $ 350            
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. [Member] | Scenario, Forecast [Member]              
Commitments and Contingencies [Line Items]              
Expects to pay an additional milestone payment         $ 700    
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Clinical Development Milestones [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments 1,000            
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Regulatory Milestone [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments 13,000            
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Sales-based and Other Milestones [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments 33,600            
Asset Purchase Agreement [Member] | 1st Order Pharmaceuticals, Inc. and Valeant Pharmaceuticals International, Inc. [Member] | Pre-commercial and Single Digit Percentage Royalty on Commercial Sales Milestone [Member]              
Commitments and Contingencies [Line Items]              
Future potential payments $ 1,500            
Medpace Clinical Development Service Agreement [Member]              
Commitments and Contingencies [Line Items]              
Service agreement, term     5 years        
Committed service obligation             $ 7,000
Contractual obligation paid       $ 3,000      
Expenses for services rendered     $ 2,715        
Current prepaid expenses     0     392  
Prepaid expenses, long term     $ 285     $ 408  
License, Manufacture and Supply Agreement [Member]              
Commitments and Contingencies [Line Items]              
Upfront fee paid | CAD   CAD 500