Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenue:
Collaboration revenue (note 9)	$ 1,767	$ 15,573	$ 28,366
Royalties	36	4	4
Revenues	1,803	15,577	28,370
Operating expenses:
Research and development	19,828	15,152	11,768
General and administrative	6,792	9,786	5,496
Total operating expenses	26,620	24,938	17,264
Income (loss) from operations	(24,817)	(9,361)	11,106
Other income (expense):
Interest income	504	542	568
Foreign exchange gain (loss)	1,316	(6,933)	1,344
Net income (loss)	$ (22,997)	$ (15,752)	$ 13,018
Net income (loss) per common share (note 3m):
Basic	$ (1.48)	$ (1.10)	$ 4.11
Diluted	$ (1.48)	$ (1.10)	$ 3.28
Weighted-average common shares outstanding (note 3m):
Basic	15,493,474	14,281,837	3,165,572
Effects of dilutive securities
Stock options			798,225
Diluted	15,493,474	14,281,837	3,963,797
Other comprehensive income (loss):
Foreign currency translation adjustment			$ (3,501)
Comprehensive income (loss)	$ (22,997)	$ (15,752)	$ 9,517