Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenue:
Collaboration revenue (note 8)	$ 412	$ 4,293	$ 1,393	$ 12,347
Royalties	1	1	34	3
Revenues	413	4,294	1,427	12,350
Operating expenses:
Research and development	5,965	3,793	15,432	10,889
General and administrative	1,779	1,321	5,350	8,219
Total operating expenses	7,744	5,114	20,782	19,108
Loss from operations	(7,331)	(820)	(19,355)	(6,758)
Other income (expense):
Interest income	114	130	336	445
Foreign exchange gain (loss)	(497)	(3,137)	2,026	(5,502)
Net loss and comprehensive loss	$ (7,714)	$ (3,827)	$ (16,993)	$ (11,815)
Net loss per common share (note 4):
Basic and diluted	$ (0.51)	$ (0.27)	$ (1.16)	$ (0.83)
Weighted-average common shares outstanding (note 4):
Basic and diluted	15,268,964	14,298,612	14,690,357	14,251,006