Statements of Operations and Comprehensive Income (Loss) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue:
Collaboration revenue (note 9)	$ 15,573	$ 28,366	$ 27,352
Royalties	4	4	4
Revenues	15,577	28,370	27,356
Operating expenses:
Research and development	15,152	11,768	12,303
General and administrative	9,786	5,496	5,341
Total operating expenses	24,938	17,264	17,644
Income (loss) from operations	(9,361)	11,106	9,712
Other income (expense):
Interest income	542	568	338
Interest expense			(64)
Foreign exchange gain (loss)	(6,933)	1,344	2,035
Gain on write-off and disposal of assets			11
Net income (loss)	(15,752)	13,018	12,032
Net income attributable to participating securities			8,199
Net income (loss) attributable to common shareholders	$ (15,752)	$ 13,018	$ 3,833
Net income (loss) per common share (note 3m):
Basic	$ (1.10)	$ 4.11	$ 2.87
Diluted	$ (1.10)	$ 3.28	$ 1.91
Weighted-average shares outstanding (note 3m):
Basic	14,281,837	3,165,572	1,337,662
Effects of dilutive securities
Stock options		798,225	659,167
Subscription rights			12,277
Diluted	14,281,837	3,963,797	2,009,106
Other comprehensive income (loss):
Foreign currency translation adjustment		$ (3,501)	$ (1,236)
Comprehensive income (loss)	$ (15,752)	$ 9,517	$ 10,796