Statements of Operations (USD $) In Thousands, except Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Revenue:
Collaboration revenue	$ 28,366	$ 27,352	$ 14,300
Royalties	4	4	8
Revenues	28,370	27,356	14,308
Operating expenses:
Research and development	11,768	12,303	10,455
General and administrative	5,496	5,341	7,006
Total operating expenses	17,264	17,644	17,461
Income (loss) from operations	11,106	9,712	(3,153)
Other income (expense):
Interest income	568	338	144
Interest expense		(64)	(93)
Foreign exchange gain (loss)	1,344	2,035	(169)
Gain (loss) on write-off and disposal of assets		11	(1,030)
Net income (loss)	13,018	12,032	(4,301)
Net income attributable to participating securities		8,199
Net income (loss) attributable to common shareholders	$ 13,018	$ 3,833	$ (4,301)
Net income (loss) per common share:
Basic (in Dollars per share)	$ 4.11	$ 2.87	$ (3.24)
Diluted (in Dollars per share)	$ 3.28	$ 1.91	$ (3.24)
Weighted-average shares outstanding:
Basic (in Shares)	3,165,572	1,337,662	1,327,460
Effects of dilutive securities
Stock options (in Shares)	798,225	659,167
Subscription rights (in Shares)		12,277
Diluted (in Shares)	3,963,797	2,009,106	1,327,460