X0306 4 2014-11-09 0 0001582313 Xenon Pharmaceuticals Inc. XENE 0001352908 Hayden Michael R C/O XENON PHARMACEUTICALS INC. 200 - 3650 GILMORE WAY BURNABY A1 V5G 4W8 BRITISH COLUMBIA, CANADA 1 0 0 0 Common Shares 2014-11-09 4 C 0 10030 A 71689 I By wife Common Shares 2014-11-09 4 C 0 2693 A 74382 I By wife Common Shares 2014-11-09 4 C 0 1504 A 75886 I By wife Series A Preferred Shares 2014-11-09 4 C 0 10030 0.00 D Common Shares 10030 0 I By wife Series B Preferred Shares 2014-11-09 4 C 0 2693 0.00 D Common Shares 2693 0 I By wife Series E Preferred Shares 2014-11-09 4 C 0 1504 0.00 D Common Shares 1504 0 I By wife The Series A Preferred Shares and Series B Preferred Shares converted into Common Shares on a 1-for-1 basis immediately prior to the completion of the Issuer's initial public offering of Common Shares and had no expiration date. The Series E Preferred Shares converted into Common Shares on a 1.2-for-1 basis immediately prior to the completion of the Issuer's initial public offering of Common Shares and had no expiration date. /s/ Barbara A. Mery, Attorney-in-fact 2014-11-12