Insider Trading Arrangements

3 Months Ended

Dec. 31, 2025

Rule 10b5-1 Trading Plans

From time to time, our officers, as defined in Rule 16a-1(f), and directors may enter into Rule 10b5-1 or non-Rule 10b5-1 trading arrangements, as each term is defined in Item 408 or Regulation S-K. During the quarter ended December 31, 2025, each of our officers listed in the table below adopted a Rule 10b5-1 trading arrangement intended to qualify as a "plan providing for eligible sell-to-cover transactions" under Rule 10b5-1(c)(1)(ii)(D)(3) under the Exchange Act. The trading arrangements are in the form of durable sell-to-cover instructions that provide for sales of common shares necessary to satisfy such individual’s tax withholding obligations incurred in connection with the vesting or settlement of restricted share units and performance share units previously granted or that could in the future be granted by the Company, whether vesting is based on the passage of time or the achievement of performance goals. The total number of shares of common shares that may be sold pursuant to the sell-to-cover instructions is not determinable and the sell-to-cover instructions will remain in place indefinitely unless revoked in writing.



Name and Position	Action	Date	Total Shares to be Sold (1)	Expiration Date (1)
Ian Mortimer President and Chief Executive Officer	Adopt	December 3, 2025	Indeterminable	Indeterminable
Thomas P. Kelly Chief Financial Officer	Adopt	December 3, 2025	Indeterminable	Indeterminable
Darren Cline Chief Commercial Officer	Adopt	December 3, 2025	Indeterminable	Indeterminable
Andrea DiFabio Chief Legal Officer and Corporate Secretary	Adopt	December 3, 2025	Indeterminable	Indeterminable
Christopher Kenney Chief Medical Officer	Adopt	December 3, 2025	Indeterminable	Indeterminable

(1)

The trading arrangements will apply to the first award of RSUs granted to the applicable officer on or after March 12, 2025; the first award of PSUs granted to such officer on or after March 11, 2024; and any RSUs or PSUs that may, from time to time following either such date, be granted to such officer by the Company, other than (i) the portion of any RSU or PSU award that vests prior to the expiration of the applicable cooling-off period as set forth in such officer’s trading arrangement, and (ii) any future granted RSUs or PSUs which by the terms of the applicable award agreement require us to withhold shares for tax withholding obligations in connection with the vesting and settlement of such RSUs or PSUs, as applicable, and therefore do not permit sell-to-cover transactions. The number of shares sold under these elections will vary based on the tax withholding obligations incurred upon vesting.

Non-Rule 10b5-1 Arrangement Adopted

false

Ian Mortimer [Member]

Trading Arrangements, by Individual

Name

Ian Mortimer

Title

President and Chief Executive Officer

Rule 10b5-1 Arrangement Adopted

true

Adoption Date

December 3, 2025