Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Operating activities:
Net loss	$ (345,910)	$ (234,330)	$ (182,393)
Adjustments to reconcile net loss to net cash used in operating activities:
Interest receivable and accretion of discounts on marketable securities	7,369	816	(5,785)
Depreciation of property, plant and equipment	2,543	2,560	2,061
Non-cash operating lease expense	1,313	1,254	1,213
Deferred income tax recovery	(3,198)	(8,864)	(292)
Stock-based compensation	53,707	50,717	32,372
Realized loss on marketable securities	625	0	0
Unrealized foreign exchange (gain) loss	73	745	(640)
Unrealized fair value gain on trading securities	0	0	(3,550)
Changes in operating assets and liabilities:
Other receivables	104	(614)	130
Prepaid expenses and other assets	(3,157)	(984)	1,574
Accounts payable and accrued liabilities	5,511	8,531	3,931
Operating lease liability	(1,297)	(1,220)	267
Other liabilities	3,199
Net cash used in operating activities	(279,118)	(181,389)	(151,112)
Investing activities:
Purchases of property, plant and equipment	(799)	(3,075)	(5,617)
Purchase of marketable securities	(355,657)	(532,268)	(793,907)
Proceeds from marketable securities	574,454	700,343	688,139
Net cash provided by (used in) investing activities	217,998	165,000	(111,385)
Financing activities:
Proceeds from offerings, net	112,151	12,083	353,487
Proceeds from exercise of stock options	4,962	47	35
Net cash provided by financing activities	117,113	12,130	353,522
Effect of exchange rate changes on cash and cash equivalents	458	(1,672)	376
Increase (decrease) in cash and cash equivalents	56,451	(5,931)	91,401
Cash and cash equivalents, beginning of year	142,712	148,643	57,242
Cash and cash equivalents, end of year	199,163	142,712	148,643
Supplemental cash flow disclosure:
Cash paid for operating lease	1,714	1,672	1,624
Cash received for lease incentives			1,489
Supplemental disclosure of non-cash transactions:
Fair Value of Stock Options and Warrants Exercised on a Cashless Basis	20,995	$ 8,305	5,250
Fair Value of Warrant and Pre-funded Warrants Exercised	$ 291		$ 35,913