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Document And Entity Information - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Feb. 23, 2026
Jun. 30, 2025
Cover [Abstract]        
Document Type 10-K      
Entity Registrant Name XENON PHARMACEUTICALS INC.      
Current Fiscal Year End Date --12-31      
Entity Public Float       $ 2,404.9
Entity Common Stock, Shares Outstanding     83,190,316  
Amendment Flag false      
Trading Symbol XENE      
Entity Central Index Key 0001582313      
Document Annual Report true      
Document Transition Report false      
Entity Current Reporting Status Yes      
Entity Voluntary Filers No      
Entity Filer Category Large Accelerated Filer      
Entity Well-known Seasoned Issuer Yes      
Document Period End Date Dec. 31, 2025      
Document Fiscal Year Focus 2025      
Document Fiscal Period Focus FY      
Document Financial Statement Error Correction [Flag] false      
Entity Shell Company false      
Entity Small Business false      
Entity Emerging Growth Company false      
Title of 12(b) Security Common Shares, without par value      
Security Exchange Name NASDAQ      
Entity Interactive Data Current Yes      
Entity Tax Identification Number 98-0661854      
Entity Address, Address Line One 200-3650 Gilmore Way      
Entity Address, City or Town Burnaby      
Entity Address, State or Province BC      
City Area Code 604      
Local Phone Number 484-3300      
Entity File Number 001-36687      
Entity Address, Postal Zip Code V5G 4W8      
Entity Incorporation, State or Country Code Z4      
Entity Address, Country CA      
ICFR Auditor Attestation Flag true      
Auditor Name PricewaterhouseCoopers LLP KPMG LLP    
Auditor Firm ID 238 85    
Auditor Location Boston, Massachusetts Vancouver, Canada    
Documents Incorporated by Reference

Portions of the Registrant’s Definitive Proxy Statement relating to the 2026 Annual Meeting of Shareholders, which will be filed with the Securities and Exchange Commission subsequent to the date hereof, are incorporated by reference into Part III of this Report. Such Proxy Statement will be filed with the Securities and Exchange Commission not later than 120 days following the end of the Registrant’s fiscal year ended December 31, 2025.

     
Auditor Opinion [Text Block]

Opinions on the Financial Statements and Internal Control over Financial Reporting

We have audited the accompanying consolidated balance sheet of Xenon Pharmaceuticals Inc. and its subsidiary (the “Company”) as of December 31, 2025, and the related consolidated statements of operations and comprehensive loss, of shareholders’ equity and of cash flows for the year then ended, including the related notes (collectively referred to as the “consolidated financial statements”). We also have audited the Company's internal control over financial reporting as of December 31, 2025, based on criteria established in Internal Control - Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO).

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of the Company as of December 31, 2025, and the results of its operations and its cash flows for the year then ended in conformity with accounting principles generally accepted in the United States of America. Also in our opinion, the Company maintained, in all material respects, effective internal control over financial reporting as of December 31, 2025, based on criteria established in Internal Control - Integrated Framework (2013) issued by the COSO.

Opinion on the Consolidated Financial Statements

We have audited the accompanying consolidated balance sheet of Xenon Pharmaceuticals Inc. (the Company) as of December 31, 2024, the related consolidated statements of operations and comprehensive loss, shareholders' equity, and cash flows for each of the years in the two-year period ended December 31, 2024, and the related notes (collectively, the consolidated financial statements). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company as of December 31, 2024, and the results of operations and its cash flows for each of the years in the two-year period ended December 31, 2024, in conformity with U.S. generally accepted accounting principles.