X0306 4 2017-08-15 0 0001582313 Xenon Pharmaceuticals Inc. XENE 0001665430 EMPFIELD JAMES R. C/O XENON PHARMACEUTICALS INC. 200 - 3650 GILMORE WAY BURNABY A1 V5G 4W8 BRITISH COLUMBIA, CANADA 0 1 0 0 SVP, Drug Discovery Common Shares 2017-08-15 4 P 0 10000 2.4824 A 10000 D /s/ Joanne Smartt, Attorney-in-fact 2017-08-17