X0306 4 2016-06-02 0 0001582313 Xenon Pharmaceuticals Inc. XENE 0001214133 SCHELLER RICHARD H C/O XENON PHARMACEUTICALS INC. 200 - 3650 GILMORE WAY BURNABY A1 V5G 4W8 BRITISH COLUMBIA, CANADA 1 0 0 0 Stock Option (Right to Buy) 7.38 2016-06-02 4 A 0 3500 0.00 A 2026-06-01 Common Shares 3500 3500 D One-third of the total shares subject to the Option shall vest on the one year anniversary of the grant date, one-third of the total shares subject to the Option shall vest on the two year anniversary of the grant date, and the balance of the total shares subject to the Option shall vest on the three year anniversary of the grant date. /s/ Joanne Smartt, Attorney-in-fact 2016-06-03