Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Operating activities:
Net loss	$ (234,330)	$ (182,393)	$ (125,373)
Adjustments to reconcile net loss to net cash used in operating activities:
Interest receivable and accretion of discounts on marketable securities	816	(5,785)	(2,598)
Depreciation of property, plant and equipment	2,560	2,061	1,405
Non-cash operating lease expense	1,254	1,213	819
Deferred income tax recovery	(8,864)	(292)	(44)
Stock-based compensation	50,717	32,372	20,376
Unrealized foreign exchange (gain) loss	745	(640)	2,729
Unrealized fair value (gain) loss on trading securities		(3,550)	2,934
Changes in operating assets and liabilities:
Accounts receivable	(614)	130	1,757
Prepaid expenses and other current assets	(984)	1,574	(10,495)
Accounts payable and accrued liabilities	8,531	3,931	8,062
Operating lease liability	(1,220)	267	(600)
Net cash used in operating activities	(181,389)	(151,112)	(101,028)
Investing activities:
Purchases of property, plant and equipment	(3,075)	(5,617)	(2,894)
Purchase of marketable securities	(532,268)	(793,907)	(551,137)
Proceeds from marketable securities	700,343	688,139	260,626
Net cash provided by (used in) investing activities	165,000	(111,385)	(293,405)
Financing activities:
Proceeds from public offerings, net	12,083	353,487	277,766
Proceeds from exercise of stock options	47	35	705
Net cash provided by financing activities	12,130	353,522	278,471
Effect of exchange rate changes on cash and cash equivalents	(1,672)	376	(2,484)
Increase (decrease) in cash and cash equivalents	(5,931)	91,401	(118,446)
Cash and cash equivalents, beginning of year	148,643	57,242	175,688
Cash and cash equivalents, end of year	142,712	148,643	57,242
Supplemental disclosures:
Cash paid for operating lease	1,672	1,624	919
Cash received for lease incentives		1,489
Supplemental disclosures of non-cash transactions:
Fair value of stock options exercised on a cashless basis	$ 8,305	5,250	4,491
Fair value of pre-funded warrants exercised		$ 35,913
Purchases of property, plant and equipment included in accounts payable and accrued liabilities			391
Right-of-use asset obtained in exchange for new operating lease liability			$ 3,019