Share Capital (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended									12 Months Ended
	Sep. 30, 2024	Nov. 30, 2023	Sep. 30, 2023	Jun. 30, 2022	Mar. 31, 2022	Jan. 31, 2022	Jun. 30, 2020	Sep. 30, 2019	Mar. 31, 2018	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2018	Aug. 31, 2018
Share Capital [Line Items]
Warrants outstanding to purchase common stock											2,173,081	3,103,864
Warrants exercise price per common share										$ 0.0001
Options granted										3,062,819	2,542,473	2,315,645
Options Outstanding Weighted Average Remaining Contractual Life in Years										7 years 3 months 10 days
Options Exercisable Weighted Average Remaining Contractual Life in Years										6 years 2 months 15 days
Aggregate fair value of options vested										$ 43,375	$ 29,233	$ 13,752
Unrecognized stock-based compensation cost not to be achieved										$ 99,779
Unrecognized stock-based compensation expected to be recognized over a period										2 years 7 months 20 days
Exercise of pre-funded warrants										0	(1,700,013)	0
Warrants exercise description											The Company may not affect the exercise of any pre-funded warrant, and a holder will not be entitled to exercise any portion of any pre-funded warrant that, upon giving effect to such exercise, would cause: (i) the aggregate number of common shares beneficially owned by such holder, together with its affiliates, to exceed 4.99% of the total number of common shares outstanding immediately after giving effect to the exercise; or (ii) the combined voting power of the Company’s securities beneficially owned by such holder, together with its affiliates, to exceed 4.99% of the combined voting power of all of the Company’s securities immediately outstanding after giving effect to the exercise, which percentage may be changed at the holder’s election to a higher or lower percentage not in excess of 19.99% upon at least 61 days’ notice to the Company.
Term Loans [Member]
Share Capital [Line Items]
Warrants outstanding to purchase common stock											40,000			40,000
Warrants exercise price per common share														$ 9.79
2019 Inducement Plan [Member]
Share Capital [Line Items]
Options granted								0
Common shares reserved for issuance								400,000
Amended and Restated 2014 Plan [Member]
Share Capital [Line Items]
Vesting period							4 years
Maximum term of each option exercised							10 years
Common shares reserved for issuance										5,882,842
Number of restricted share awards, restricted share unit awards or performance awards available for issue										1,000,000
Common Shares [Member]
Share Capital [Line Items]
Shares issued										310,000	10,701,842	9,357,348
Conversion of shares					1,016,000							1,016,000	1,852,000
Jefferies and Stifel [Member] | ATM [Member]
Share Capital [Line Items]
Sale proceeds of common shares			$ 29,508							$ 12,083
Jefferies and Stifel [Member] | ATM [Member] | Maximum [Member]
Share Capital [Line Items]
Gross proceeds from issuable of common stock										$ 350,000
Jefferies and Stifel [Member] | ATM [Member] | Common Shares [Member]
Share Capital [Line Items]
Shares issued	855,685									310,000
Jefferies and Stifel [Member] | Underwritten Public Offering [Member]
Share Capital [Line Items]
Sale proceeds from issuance of pre funded warrants											$ 23,477	$ 9,387
Neurocrine Biosciences [Member] | License and Collaboration Agreement [Member]
Share Capital [Line Items]
Sale proceeds of common shares						$ 8,250
Shares issued						258,986
Aggregate purchase price per share						$ 31.855
Premium						$ 374
Jefferies, Stifel, J.P. Morgan Securities LLC and SVB Securities LLC [Member] | Underwritten Public Offering [Member]
Share Capital [Line Items]
Sale proceeds of common shares				$ 269,890
Shares issued				9,098,362
Shares price				$ 30.50
Warrants outstanding to purchase common stock				327,868
Warrants issued price per pre funded warrant				$ 30.4999
Warrants exercise price per common share				$ 0.0001
Jefferies, Stifel, J.P. Morgan Securities LLC and SVB Securities LLC [Member] | Over Allotment [Member]
Share Capital [Line Items]
Shares issued				1,229,508
J.P. Morgan, Jefferies, BofA Securities, Inc., Stifel, and RBC Capital Markets, LLC [Member] | Underwritten Public Offering [Member]
Share Capital [Line Items]
Sale proceeds of common shares											$ 323,979
Shares issued		9,846,157
Shares price		$ 32.5
Warrants outstanding to purchase common stock		769,230
Warrants issued price per pre funded warrant		$ 32.4999
Warrants exercise price per common share		$ 0.0001
J.P. Morgan, Jefferies, BofA Securities, Inc., Stifel, and RBC Capital Markets, LLC [Member] | Over Allotment [Member]
Share Capital [Line Items]
Shares issued		1,384,615
Series1 Preferred Shares
Share Capital [Line Items]
Conversion of shares					1,016,000								1,852,000
BVF Partners L.P [Member] | Exchange Agreement [Member] | Common Shares [Member]
Share Capital [Line Items]
Shares cancelled									2,868,000
BVF Partners L.P [Member] | Exchange Agreement [Member] | Series1 Preferred Shares
Share Capital [Line Items]
Preferred shares convertible into common shares									one-for-one
Shares issued									2,868,000
PSUs
Share Capital [Line Items]
Unrecognized stock-based compensation cost to be achieved										$ 2,267
Unrecognized stock-based compensation cost not to be achieved										$ 4,609
Shares granted										210,000
Weighted average grant date fair value										$ 43.9
Shares vested										0