Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023
Operating activities:
Net loss	$ (168,645)	$ (137,650)
Items not involving cash:
Accretion of discounts on marketable securities	(859)	(5,849)
Depreciation	1,927	2,690
Deferred income tax recovery	(252)	(92)
Stock-based compensation	37,118	23,190
Unrealized foreign exchange (gain) loss	182	(753)
Unrealized fair value gain on trading securities		(3,404)
Changes in operating assets and liabilities:
Accounts receivable	(67)	424
Prepaid expenses and other current assets	1,245	4,103
Accounts payable and accrued expenses	2,347	1,630
Net cash used in operating activities	(127,004)	(115,711)
Investing activities:
Purchases of property, plant and equipment	(2,292)	(5,539)
Purchases of marketable securities	(465,914)	(417,319)
Proceeds from marketable securities	534,703	551,263
Net cash provided by investing activities	66,497	128,405
Financing activities:
Issuance of common shares, net of issuance costs (note 9a)		29,508
Net cash provided by financing activities		29,508
Effect of exchange rate changes on cash and cash equivalents	(515)	130
Increase (decrease) in cash and cash equivalents	(61,022)	42,332
Cash and cash equivalents, beginning of period	148,643	57,242
Cash and cash equivalents, end of period	87,621	99,574
Supplemental disclosure:
Cash paid for operating lease	1,245	1,219
Cash received for lease incentives		1,265
Supplemental disclosures of non-cash transactions:
Fair value of stock options exercised on a cashless basis	$ 5,440	3,183
Fair value of pre-funded warrants exercised		24,141
Increase in operating lease liability and accounts receivable related to lease incentives claimed in the period		$ 226