144 0001619962 XXXXXXXX LIVE 0001582313 Xenon Pharmaceuticals Inc. 001-36687 200-3650 Gilmore Way Burnaby A1 V5G 4W8 (604)-484-3300 ROBIN SHERRINGTON Officer Common Shares Morgan Stanley Wealth Management Canada Inc.

Suite 1500, 600 - 3 Avenue SW Calgary Z4 T2P 0G5

7137 330288 75432482 03/07/2024 NASDAQ Common Shares 03/07/2024 Exercise of Options Issuer N 7137 03/07/2024 Net Exercise Y 03/07/2024 /s/ Robin Sherrington