144 0001643085 XXXXXXXX LIVE 0001582313 Xenon Pharmaceuticals Inc. 001-36687 200-3650 Gilmore Way Burnaby A1 V5G 4W8 (604)-484-3300 STEVEN GANNON Director Common Shares RBC Wealth Management

1501 ave. McGill College Suite 2150 Montreal Z4 H3A 3M8

13000 600310 75432482 03/07/2024 NASDAQ Common Shares 08/11/2017 Open Market Purchase Open Market Purchase N 15000 08/11/2017 Cash Y 03/07/2024 /s/ Steve Gannon