Consolidated Statements of Shareholders' Equity (Unaudited) - USD ($) $ in Thousands	Total	Convertible Preferred Shares [Member]	Common Shares [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Loss [Member]
Balance at Dec. 31, 2021	$ 550,033	$ 7,732	$ 783,170	$ 117,495	$ (357,374)	$ (990)
Balance (in Shares) at Dec. 31, 2021		1,016,000	51,634,752
Net loss for the period	(19,670)				(19,670)
Issuance of common shares and pre-funded warrants, net of issuance costs (note 8a and note 8c)	7,876		$ 7,876
Issuance of common shares and pre-funded warrants, net of issuance costs (note 8a and note 8c) (in shares)			258,986
Conversion of preferred shares to common shares (note 8b)		$ (7,732)	$ 7,732
Conversion of preferred shares to common shares (note 8b) (in shares)		(1,016,000)	1,016,000
Stock-based compensation expense	3,614			3,614
Issued pursuant to exercise of stock options			$ 1,529	(1,529)
Issued pursuant to exercise of stock options (in Shares)			149,311
Balance at Mar. 31, 2022	541,853		$ 800,307	119,580	(377,044)	(990)
Balance (in Shares) at Mar. 31, 2022			53,059,049
Balance at Dec. 31, 2021	550,033	$ 7,732	$ 783,170	117,495	(357,374)	(990)
Balance (in Shares) at Dec. 31, 2021		1,016,000	51,634,752
Net loss for the period	$ (87,978)
Issued pursuant to exercise of stock options (in Shares)	718,472
Balance at Sep. 30, 2022	$ 753,119		$ 1,064,698	136,728	(445,352)	(2,955)
Balance (in Shares) at Sep. 30, 2022			62,542,542
Balance at Mar. 31, 2022	541,853		$ 800,307	119,580	(377,044)	(990)
Balance (in Shares) at Mar. 31, 2022			53,059,049
Net loss for the period	(31,158)				(31,158)
Issuance of common shares and pre-funded warrants, net of issuance costs (note 8a and note 8c)	269,890		$ 260,503	9,387
Issuance of common shares and pre-funded warrants, net of issuance costs (note 8a and note 8c) (in shares)			9,098,362
Stock-based compensation expense	5,208			5,208
Issued pursuant to exercise of stock options			$ 880	(880)
Issued pursuant to exercise of stock options (in Shares)			85,472
Balance at Jun. 30, 2022	785,793		$ 1,061,690	133,295	(408,202)	(990)
Balance (in Shares) at Jun. 30, 2022			62,242,883
Net loss for the period	(37,150)				(37,150)
Stock-based compensation expense	5,742			5,742
Issued pursuant to exercise of stock options	$ 699		$ 3,008	(2,309)
Issued pursuant to exercise of stock options (in Shares)	369,334		299,659
Other comprehensive income (loss) (note 5)	$ (1,965)					(1,965)
Balance at Sep. 30, 2022	753,119		$ 1,064,698	136,728	(445,352)	(2,955)
Balance (in Shares) at Sep. 30, 2022			62,542,542
Balance at Dec. 31, 2022	721,497		$ 1,065,136	142,108	(482,747)	(3,000)
Balance (in Shares) at Dec. 31, 2022			62,587,701
Net loss for the period	(41,727)				(41,727)
Conversion of pre-funded warrants to common shares (note 8c)			$ 7,379	(7,379)
Conversion of pre-funded warrants to common shares (note 8c) (in shares)			425,000
Stock-based compensation expense	5,994			5,994
Issued pursuant to exercise of stock options			$ 635	(635)
Issued pursuant to exercise of stock options (in Shares)			94,319
Other comprehensive income (loss) (note 5)	1,180					1,180
Balance at Mar. 31, 2023	686,944		$ 1,073,150	140,088	(524,474)	(1,820)
Balance (in Shares) at Mar. 31, 2023			63,107,020
Balance at Dec. 31, 2022	721,497		$ 1,065,136	142,108	(482,747)	(3,000)
Balance (in Shares) at Dec. 31, 2022			62,587,701
Net loss for the period	$ (137,650)
Conversion of pre-funded warrants to common shares (note 8c) (in shares)			1,275,000
Issued pursuant to exercise of stock options (in Shares)	398,097
Balance at Sep. 30, 2023	$ 636,592		$ 1,121,968	137,974	(620,397)	(2,953)
Balance (in Shares) at Sep. 30, 2023			65,002,249
Balance at Mar. 31, 2023	686,944		$ 1,073,150	140,088	(524,474)	(1,820)
Balance (in Shares) at Mar. 31, 2023			63,107,020
Net loss for the period	(47,461)				(47,461)
Conversion of pre-funded warrants to common shares (note 8c)			$ 7,379	(7,379)
Conversion of pre-funded warrants to common shares (note 8c) (in shares)			425,000
Stock-based compensation expense	8,453			8,453
Issued pursuant to exercise of stock options			$ 2,479	(2,479)
Issued pursuant to exercise of stock options (in Shares)			186,330
Other comprehensive income (loss) (note 5)	(1,479)					(1,479)
Balance at Jun. 30, 2023	646,457		$ 1,083,008	138,683	(571,935)	(3,299)
Balance (in Shares) at Jun. 30, 2023			63,718,350
Net loss for the period	(48,462)				(48,462)
Issuance of common shares and pre-funded warrants, net of issuance costs (note 8a and note 8c)	29,508		$ 29,508
Issuance of common shares and pre-funded warrants, net of issuance costs (note 8a and note 8c) (in shares)			855,685
Conversion of pre-funded warrants to common shares (note 8c)			$ 9,383	(9,383)
Conversion of pre-funded warrants to common shares (note 8c) (in shares)			425,000
Stock-based compensation expense	$ 8,743			8,743
Issued pursuant to exercise of stock options			$ 69	(69)
Issued pursuant to exercise of stock options (in Shares)	6,351		3,214
Other comprehensive income (loss) (note 5)	$ 346					346
Balance at Sep. 30, 2023	$ 636,592		$ 1,121,968	$ 137,974	$ (620,397)	$ (2,953)
Balance (in Shares) at Sep. 30, 2023			65,002,249