Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Operating activities:
Net loss	$ (89,188)	$ (50,828)
Items not involving cash:
Depreciation	956	751
Deferred income tax expense	64	154
Stock-based compensation	14,447	8,822
Unrealized foreign exchange (gain) loss	(452)	492
Unrealized fair value (gain) loss on trading securities	(2,914)	4,650
Changes in operating assets and liabilities:
Accounts receivable	269	235
Prepaid expenses and other current assets	4,199	439
Accounts payable and accrued expenses	4,987	(11)
Net cash used in operating activities	(67,632)	(35,296)
Investing activities:
Purchases of property, plant and equipment	(4,339)	(756)
Purchases of marketable securities	(270,554)	(141,638)
Proceeds from marketable securities	349,417	94,823
Net cash provided by (used in) investing activities	74,524	(47,571)
Financing activities:
Issuance of common shares and pre-funded warrants, net of issuance costs (note 8a and note 8c)		277,766
Net cash provided by financing activities		277,766
Effect of exchange rate changes on cash and cash equivalents	418	(600)
Increase in cash and cash equivalents	7,310	194,299
Cash and cash equivalents, beginning of period	57,242	175,688
Cash and cash equivalents, end of period	64,552	369,987
Supplemental disclosures:
Interest received	6,366	3,509
Cash paid for operating lease	709	410
Supplemental disclosures of non-cash transactions:
Fair value of stock options exercised on a cashless basis	3,114	$ 2,409
Fair value of pre-funded warrants exercised	14,758
Increase in operating lease liability and accounts receivable related to lease incentives claimed in the period	$ 1,380