Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 69,512	$ 57,242
Marketable securities (note 5)	457,531	534,845
Accounts receivable	2,222	986
Prepaid expenses and other current assets	4,086	7,225
Total current assets	533,351	600,298
Marketable securities, long-term (note 5)	160,265	128,682
Operating lease right-of-use asset, net (note 6)	10,097	10,406
Property, plant and equipment, net	7,975	6,500
Deferred tax assets	221	509
Prepaid expenses, long-term	7,959	7,751
Total assets	719,868	754,146
Current liabilities:
Accounts payable and accrued expenses (note 7)	21,297	22,214
Operating lease liability (note 6)	1,194	488
Total current liabilities	22,491	22,702
Operating lease liability, long-term (note 6)	10,433	9,947
Total liabilities	32,924	32,649
Shareholders’ equity:
Common shares, without par value; unlimited shares authorized; issued and outstanding: 63,107,020 (December 31, 2022 - 62,587,701) (note 8)	1,073,150	1,065,136
Additional paid-in capital	140,088	142,108
Accumulated deficit	(524,474)	(482,747)
Accumulated other comprehensive loss	(1,820)	(3,000)
Total shareholders' equity	686,944	721,497
Total liabilities and shareholders’ equity	719,868	754,146
Commitments and contingencies (note 10)