Consolidated Statement of Shareholders' Equity - USD ($) $ in Thousands	Total	Convertible Preferred Shares [Member]	Common Shares [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Loss [Member]
Balance at Dec. 31, 2019	$ 91,977	$ 7,732	$ 294,244	$ 40,646	$ (249,655)	$ (990)
Balance (in Shares) at Dec. 31, 2019		1,016,000	28,139,228
Net loss	(28,837)				(28,837)
Issuance of common shares and pre-funded warrants, net of issuance costs (note 12a and note 12e)	102,456		$ 102,456
Issuance of common shares and pre-funded warrants, net of issuance costs (note 12a and note 12e) (in shares)			6,759,187
Stock-based compensation expense (note 12c)	5,677			5,677
Issued pursuant to exercise of stock options	$ 82		$ 1,048	(966)
Issued pursuant to exercise of stock options (in Shares)	171,812		113,710
Balance at Dec. 31, 2020	$ 171,355	$ 7,732	$ 397,748	45,357	(278,492)	(990)
Balance (in Shares) at Dec. 31, 2020		1,016,000	35,012,125
Net loss	(78,882)				(78,882)
Issuance of common shares and pre-funded warrants, net of issuance costs (note 12a and note 12e)	447,283		$ 381,567	65,716
Issuance of common shares and pre-funded warrants, net of issuance costs (note 12a and note 12e) (in shares)			16,143,472
Stock-based compensation expense (note 12c)	10,017			10,017
Issued pursuant to exercise of stock options	$ 260		$ 3,855	(3,595)
Issued pursuant to exercise of stock options (in Shares)	690,284		479,155
Balance at Dec. 31, 2021	$ 550,033	$ 7,732	$ 783,170	117,495	(357,374)	(990)
Balance (in Shares) at Dec. 31, 2021		1,016,000	51,634,752
Net loss	(125,373)				(125,373)
Issuance of common shares and pre-funded warrants, net of issuance costs (note 12a and note 12e)	277,766		$ 268,379	9,387
Issuance of common shares and pre-funded warrants, net of issuance costs (note 12a and note 12e) (in shares)			9,357,348
Conversion of preferred share to common shares (note 12d)		$ (7,732)	$ 7,732
Conversion of preferred shares to common shares (note 12d) (in shares)		(1,016,000)	1,016,000
Stock-based compensation expense (note 12c)	20,376			20,376
Issued pursuant to exercise of stock options	$ 705		$ 5,855	(5,150)
Issued pursuant to exercise of stock options (in Shares)	780,725		579,601
Other comprehensive loss (note 7)	$ (2,010)					(2,010)
Balance at Dec. 31, 2022	$ 721,497		$ 1,065,136	$ 142,108	$ (482,747)	$ (3,000)
Balance (in Shares) at Dec. 31, 2022			62,587,701