Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 57,242	$ 175,688
Marketable securities (note 7)	534,845	376,086
Accounts receivable	986	2,765
Prepaid expenses and other current assets	7,225	4,481
Total current assets	600,298	559,020
Marketable securities, long-term (note 7)	128,682	0
Operating lease right-of-use asset, net (note 9)	10,406	8,056
Property, plant and equipment, net (note 8)	6,500	4,466
Deferred tax assets (note 15)	509	465
Prepaid expenses, long-term	7,751	0
Total assets	754,146	572,007
Current liabilities:
Accounts payable and accrued expenses (note 10)	22,214	13,717
Operating lease liability (note 9)	488	605
Total current liabilities	22,702	14,322
Operating lease liability, long-term (note 9)	9,947	7,652
Total liabilities	32,649	21,974
Shareholders’ equity:
Preferred shares, without par value; unlimited shares authorized; issued and outstanding: nil (December 31, 2021 - 1,016,000) (note 12)		7,732
Common shares, without par value; unlimited shares authorized; issued and outstanding: 62,587,701 (December 31, 2021 - 51,634,752) (note 12)	1,065,136	783,170
Additional paid-in capital	142,108	117,495
Accumulated deficit	(482,747)	(357,374)
Accumulated other comprehensive loss	(3,000)	(990)
Total shareholders' equity	721,497	550,033
Total liabilities and shareholders’ equity	754,146	572,007
Commitments and contingencies (note 14)