Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Operating activities:
Net loss	$ (87,978)	$ (53,318)
Items not involving cash:
Depreciation	1,109	636
Deferred income tax recovery	(49)	(288)
Stock-based compensation	14,564	7,312
Unrealized foreign exchange loss	3,454	451
Unrealized fair value loss on trading securities	4,944	72
Changes in operating assets and liabilities:
Accounts receivable	242	(940)
Prepaid expenses and other current assets	(4,028)	(490)
Accounts payable and accrued expenses	2,044	(787)
Deferred revenue	0	(1,440)
Net cash used in operating activities	(65,698)	(48,792)
Investing activities:
Purchases of property, plant and equipment	(1,142)	(1,536)
Purchases of marketable securities	(436,393)	(132,280)
Proceeds from marketable securities	155,867	102,479
Net cash used in investing activities	(281,668)	(31,337)
Financing activities:
Issuance of common shares and pre-funded warrants, net of issuance costs (note 9a and note 9c)	277,766	123,345
Issuance of common shares pursuant to exercise of stock options	699	245
Net cash provided by financing activities	278,465	123,590
Effect of exchange rate changes on cash and cash equivalents	(3,298)	(661)
Increase (decrease) in cash and cash equivalents	(72,199)	42,800
Cash and cash equivalents, beginning of period	175,688	45,009
Cash and cash equivalents, end of period	103,489	87,809
Supplemental disclosures:
Interest received	6,206	2,428
Cash paid for operating lease	638	619
Supplemental disclosures of non-cash transactions:
Fair value of stock options exercised on a cashless basis	4,085	1,583
Increase in operating lease liability and accounts receivable related to lease incentives claimed in the period	$ 0	$ 493