<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-11-06</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
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        <issuerName>Cannabis Sativa, Inc.</issuerName>
        <issuerTradingSymbol>CBDS</issuerTradingSymbol>
    </issuer>

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            <rptOwnerName>TOBIAS DAVID</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>PO BOX 1602</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MESQUITE</rptOwnerCity>
            <rptOwnerState>NV</rptOwnerState>
            <rptOwnerZipCode>89024</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isOfficer>1</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>CEO</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

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                    <value></value>
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        <nonDerivativeTransaction>
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                <transactionFormType>4</transactionFormType>
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                <value></value>
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                <transactionShares>
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                <transactionPricePerShare>
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                <sharesOwnedFollowingTransaction>
                    <value>3265614.0000</value>
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                <directOrIndirectOwnership>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
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                <transactionFormType>4</transactionFormType>
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                <value></value>
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            <transactionAmounts>
                <transactionShares>
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                <transactionPricePerShare>
                    <value>0.7300</value>
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                    <value>3255614.0000</value>
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                <directOrIndirectOwnership>
                    <value>D</value>
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        <nonDerivativeTransaction>
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                <directOrIndirectOwnership>
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                <transactionShares>
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                <directOrIndirectOwnership>
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                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
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                <transactionPricePerShare>
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                    <value>A</value>
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            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
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                <directOrIndirectOwnership>
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        <nonDerivativeTransaction>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
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            <transactionAmounts>
                <transactionShares>
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                <directOrIndirectOwnership>
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        <nonDerivativeTransaction>
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                <directOrIndirectOwnership>
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                <value>2021-03-01</value>
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                <directOrIndirectOwnership>
                    <value>D</value>
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                <natureOfOwnership>
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                </natureOfOwnership>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
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                <value></value>
            </transactionTimeliness>
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                    <value>D</value>
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                <directOrIndirectOwnership>
                    <value>D</value>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
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                <value>Common Stock</value>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
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            <transactionAmounts>
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                    <value>0.9700</value>
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                    <value>D</value>
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                <sharesOwnedFollowingTransaction>
                    <value>3271370.0000</value>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
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                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Conversion from Preferred to Common Stock</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ David Tobias</signatureName>
        <signatureDate>2021-09-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
