X0306 4 2014-09-26 0 0001439222 AGIOS PHARMACEUTICALS INC AGIO 0001581992 Goddard Glenn C/O AGIOS PHARMACEUTICALS, INC. 38 SIDNEY STREET, 2ND FLOOR CAMBRIDGE MA 02139 0 1 0 0 Senior Vice President, Finance Common stock 2014-09-26 4 M 0 227 0.6875 A 227 D Common stock 2014-09-26 4 M 0 9725 2.34 A 9952 D Common stock 2014-09-26 4 M 0 7548 9.05 A 17500 D Common stock 2014-09-26 4 S 0 17500 56.53 D 0 D Stock option (right to buy) 0.6875 2014-09-26 4 M 0 227 0.00 D 2021-09-14 Common stock 227 129271 D Stock option (right to buy) 2.34 2014-09-26 4 M 0 9725 0.00 D 2022-04-05 Common stock 9725 119546 D Stock option (right to buy) 9.05 2014-09-26 4 M 0 7548 0.00 D 2023-04-29 Common stock 7548 111998 D This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $55.00 to $57.88. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This option was granted on September 15, 2011. The shares underlying this option vest as to 25% of the underlying shares on September 15, 2012, with the remaining 75% vesting in 36 equal monthly installments thereafter. This option was granted on April 6, 2012 for the purchase of 29,090 shares of common stock. The option vests as to 25% of the underlying shares upon the achievement of a performance milestone, as to an additional 50% upon the achievement of a second performance milestone, and as to the remaining 25% on the first anniversary of the first date that both performance milestones were achieved. The performance criteria for the first performance milestone were met on March 18, 2013. The performance criteria for the second performance milestone were met on April 4, 2014, resulting in the vesting of the option as to 14,545 shares, and the remaining 7,273 shares will vest on April 4, 2015. This option was granted on April 30, 2013 for the purchase of 14,545 shares of common stock. The option vests as to 25% upon the achievement of a performance milestone, as to an additional 50% of the underlying shares upon the achievement of a second performance milestone, and as to the remaining 25% on the first anniversary of the first date that both performance milestones were achieved. The performance criteria for the first performance milestone was met on January 17, 2014. The performance criteria for the second performance milestone was met on April 4, 2014, resulting in the vesting of the option as to 7,273 shares, and the remaining 3,636 shares will vest on April 4, 2015. /s/ Glenn Goddard 2014-09-29