X0306 4 2017-07-19 0 0001439222 AGIOS PHARMACEUTICALS INC AGIO 0001581950 Cantley Lewis Clayton Jr. C/O AGIOS PHARMACEUTICALS, INC. 88 SIDNEY STREET CAMBRIDGE MA 02139 1 0 0 0 Common stock 2017-07-19 4 S 0 3000 56.15 D 86697 D Common stock 2017-07-19 4 S 0 3000 56.15 D 86737 I See footnote Common stock 2017-07-19 4 S 0 500 56.11 D 86197 D Common stock 2017-07-19 4 S 0 500 56.11 D 86237 I See footnote Common stock 2017-07-20 4 S 0 500 57.12 D 85697 D Common stock 2017-07-20 4 S 0 500 57.12 D 85737 I See footnote Common stock 2017-07-20 4 S 0 500 57.13 D 85197 D Common stock 2017-07-20 4 S 0 500 57.13 D 85237 I See footnote Common stock 25000 I See footnote Common stock 25000 I See footnote This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $55.79 to $56.72. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. Shares held by Vicki Lee Sato, who is the reporting person's spouse. The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $55.85 to $56.49. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $56.18 to $57.58. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $56.18 to $57.59. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. Shares held by grantor retained annuity trusts for the benefit of the reporting person and his two children, of which the reporting person is trustee and sole annuitant. Shares held by grantor retained annuity trusts for the benefit of the reporting person's spouse and their two children, of which the reporting person's spouse is trustee and sole annuitant. /s/ Andrew Hirsch, as Attorney-in-fact for Lewis C. Cantley Jr. 2017-07-21