X0306 4 2022-04-15 0 0001580063 PROGENITY, INC. PROG 0001622268 dEsparbes Eric C/O PROGENITY, INC. 4330 LA JOLLA VILLAGE DRIVE, SUITE 300 SAN DIEGO CA 92122 0 1 0 0 Chief Financial Officer Common Stock 2022-04-15 4 A 0 231693 0.00 A 423171 D Stock Option (Right to Buy) 1.00 2022-04-15 4 A 0 375032 0.00 A 2032-04-15 Common Stock 375032 375032 D Consists of 231,693 restricted stock units, 25% of which will vest on May 15, 2023, with the remaining shares vesting in equal semi-annual installments through May 15, 2026, subject to the Reporting Person's continued service to the Issuer. This option represents the right to purchase 375,032 shares of the Issuer's common stock, 7,813 of which vested upon grant, with the remaining shares vesting in equal monthly installments through March 15, 2026, subject to the Reporting Person's continued service to the Issuer. /s/ Will Pridgen, Attorney-in-Fact for Eric d'Esparbes 2022-04-19