X0306 4 2022-04-15 0 0001580063 PROGENITY, INC. PROG 0001321466 NEUMANN CLARKE C/O PROGENITY, INC. 4330 LA JOLLA VILLAGE DRIVE, SUITE 300 SAN DIEGO CA 92122 0 1 0 0 See Remarks Common Stock 2022-04-15 4 A 0 184843 0.00 A 316625 D Stock Option (Right to Buy) 1.00 2022-04-15 4 A 0 299197 0.00 A 2032-04-15 Common Stock 299197 299197 D Consists of 184,843 restricted stock units, 25% of which will vest on May 15, 2023, with the remaining shares vesting in equal semi-annual installments through May 15, 2026, subject to the Reporting Person's continued service to the Issuer. This option represents the right to purchase 299,197 shares of the Issuer's common stock, 6,233 of which vested upon grant, with the remaining shares vesting in equal monthly installments through March 15, 2026, subject to the Reporting Person's continued service to the Issuer. Senior Vice President, General Counsel and Secretary /s/ Will Pridgen, Attorney-in-Fact for Clarke Neumann 2022-04-19