X0306 4 2021-06-14 0 0001580063 PROGENITY, INC. PROG 0001199310 NUSSBAUM SAMUEL R MD C/O PROGENITY, INC. 4330 LA JOLLA VILLAGE DRIVE, SUITE 200 SAN DIEGO CA 92122 1 0 0 0 Common Stock 2021-06-14 4 A 0 29183 0.00 A 47518 D Stock Option (Right to Buy) 3.17 2021-06-14 4 A 0 51724 0.00 A 2031-06-14 Common Stock 51724 51724 D Represents 29,183 restricted stock units, which vest in full on the earlier of (1) June 14, 2022 or (2) the date of the Issuer's 2022 annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer. This option represents the right to purchase 51,724 shares of the Issuer's common stock, which vest in full on the earlier of (1) June 14, 2022 or (2) the date of the Issuer's 2022 annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer. /s/ Will Pridgen, Attorney-in-Fact for Samuel R. Nussbaum 2021-06-16