X0306 4 2021-06-14 0 0001580063 PROGENITY, INC. PROG 0001589714 Athyrium Opportunities Fund (A) LP 325 N. SAINT PAUL STREET, SUITE 4900 DALLAS TX 75201 0 0 1 0 0001815261 Athyrium Opportunities 2020 LP 505 FIFTH AVENUE, FLOOR 18 NEW YORK NY 10017 0 0 1 0 0001815268 Athyrium Opportunities III Acquisition 2 LP 505 FIFTH AVENUE, FLOOR 18 NEW YORK NY 10017 0 0 1 0 0001815260 Athyrium Opportunities III Co-Invest 1 LP 505 FIFTH AVENUE, FLOOR 18 NEW YORK NY 10017 0 0 1 0 0001815259 Athyrium Opportunities Associates Co-Invest LLC 505 FIFTH AVENUE, FLOOR 18 NEW YORK NY 10017 0 0 1 0 0001815211 Athyrium Opportunities Associates III GP LLC 505 FIFTH AVENUE, FLOOR 18 NEW YORK NY 10017 0 0 1 0 0001815262 Athyrium Opportunities Associates III LP 505 FIFTH AVENUE, FLOOR 18 NEW YORK NY 10017 0 0 1 0 0001540542 Athyrium Opportunities Fund (B) LP 325 N. SAINT PAUL STREET, SUITE 4900 DALLAS TX 75201 0 0 1 0 0001815479 Athyrium Opportunities Associates GP LLC 325 N. SAINT PAUL STREET, SUITE 4900 DALLAS TX 75201 0 0 1 0 0001815474 Athyrium Opportunities Associates LP 325 N. SAINT PAUL STREET, SUITE 4900 DALLAS TX 75201 0 0 1 0 Common Stock 2021-06-14 4 P 0 8097166 2.47 A 36396907 I See footnotes Warrant 2.84 2021-06-14 4 P 0 8097166 2.47 A 2021-06-14 2026-06-14 Common Stock 8097166 8097166 I See footnotes The shares of the Issuer's common stock and the Warrant were purchased for $2.47 per unit, with each unit consisting of one share of the Issuer's common stock and the right to buy an additional share of the Issuer's common stock for the exercise price specified in the Warrant. The 8,097,166 shares of the Issuer's common stock and the Warrant are directly owned by Athyrium Opportunities III Acquisition 2 LP. Athyrium Opportunities Associates III GP LLC is the general partner of Athyrium Opportunities Associates III LP, which is the general partner of Athyrium Opportunities III Acquisition 2 LP. Athyrium Funds GP Holdings, LLC is the managing member of Athyrium Opportunities Associates III GP LLC. Jeffrey Ferrell is the managing member of Athyrium Funds GP Holdings, LLC and the President of Athyrium Opportunities Associates III GP LLC. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein, except to the extent of such Reporting Person's pecuniary interest therein. The Warrant represents a right to buy 8,097,166 shares of the Issuer's common stock at an exercise price of $2.84 per share. The Warrant is exercisable at any time and from time to time prior to June 14, 2026. Because no more than 10 reporting persons can file any one Form 4 through the Securities and Exchange Commission's EDGAR system, certain affiliates of the Reporting Persons have filed a separate Form 4. /s/ Athyrium Opportunities Fund (A) LP, by Christian Neira, Authorized Signatory 2021-06-14 /s/ Athyrium Opportunities 2020 LP, by Athyrium Opportunities Associates III LP, its general partner, by Athyrium Opportunities Associates III GP LLC, its general partner, by Andrew Hyman, Senior Vice President, Secretary 2021-06-14 /s/ Athyrium Opportunities Fund (B) LP, by Christian Neira, Authorized Signatory 2021-06-14 /s/ Athyrium Opportunities III Acquisition 2 LP, by Athyrium Opportunities Associates III LP, its general partner, by Athyrium Opportunities Associates III GP LLC, its general partner, by Andrew Hyman, Senior Vice President, Secretary 2021-06-14 /s/ Athyrium Opportunities III Co-Invest 1 LP, by Athyrium Opportunities Associates Co-Invest LLC, its general partner, by Andrew Hyman, Senior Vice President, Secretary 2021-06-14 /s/ Athyrium Opportunities Associates Co-Invest LLC, by Andrew Hyman, Senior Vice President, Secretary 2021-06-14 /s/ Athyrium Opportunities Associates III GP LLC, by Andrew Hyman, Senior Vice President, Secretary 2021-06-14 /s/ Athyrium Opportunities Associates III LP, by Athyrium Opportunities Associates III GP LLC, its general partner, by Andrew Hyman, Senior Vice President, Secretary 2021-06-14 /s/ Athyrium Opportunities Associates GP LLC, by Christian Neira, Authorized Signatory 2021-06-14 /s/ Athyrium Opportunities Associates LP, by Christian Neira, Authorized Signatory 2021-06-14