X0306 4 2020-11-15 0 0001580063 PROGENITY, INC. PROG 0001813862 Silvestry Damon C/O PROGENITY, INC. 4330 LA JOLLA VILLAGE DRIVE, SUITE 200 SAN DIEGO CA 92122 0 1 0 0 Chief Operating Officer Common Stock 2020-11-15 4 A 0 75000 0.00 A 99279 D Stock Option (Right to Buy) 4.47 2020-11-15 4 A 0 150000 0.00 A 2030-11-15 Common Stock 150000 150000 D Consists of 75,000 restricted stock units ("RSUs"), one quarter of which will vest on November 15, 2021, with the remaining three quarters vesting in equal semi-annual installments over the following three years, subject to the Reporting Person's continued service to the Issuer. Consists of 99,279 RSUs. This option represents the right to purchase a total of 150,000 shares of the Issuer's common stock, one quarter of which will vest on November 15, 2021, with the remaining three quarters vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer. /s/ Will Pridgen, Attorney-in-Fact for Damon Silvestry 2020-11-17