The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 16,910 296,300 SH   SOLE 296,300 0 0
ABBOTT LABS COM 002824100 633 11,100 SH   DFND 1 0 11,100 0
AERIE PHARMACEUTICALS INC COM 00771V108 598 10,000 SH   DFND 1 0 10,000 0
AERIE PHARMACEUTICALS INC COM 00771V108 16,037 268,400 SH   SOLE 268,400 0 0
AETNA INC NEW COM 00817Y108 920 5,100 SH   DFND 1 0 5,100 0
AETNA INC NEW COM 00817Y108 24,371 135,100 SH   SOLE 135,100 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 326 28,460 SH   DFND 1 0 28,460 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 8,684 758,410 SH   SOLE 758,410 0 0
ALLERGAN PLC 5.5% CNV PFD A G0177J116 528 900 PRN   DFND 1 0 900 0
ALLERGAN PLC 5.5% CNV PFD A G0177J116 14,129 24,100 PRN   SOLE 24,100 0 0
ALLERGAN PLC SHS G0177J108 294 1,800 SH   DFND 1 0 1,800 0
ALLERGAN PLC SHS G0177J108 7,705 47,100 SH   SOLE 47,100 0 0
AVEXIS INC COM 05366U100 232 2,100 SH   DFND 1 0 2,100 0
AVEXIS INC COM 05366U100 6,198 56,000 SH   SOLE 56,000 0 0
CERNER CORP COM 156782104 411 6,100 SH   DFND 1 0 6,100 0
CERNER CORP COM 156782104 10,978 162,900 SH   SOLE 162,900 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 6,891 266,377 SH   SOLE 266,377 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 258 9,968 SH   DFND 1 0 9,968 0
CVS HEALTH CORP COM 126650100 834 11,500 SH   DFND 1 0 11,500 0
CVS HEALTH CORP COM 126650100 22,040 304,000 SH   SOLE 304,000 0 0
ENDOLOGIX INC COM 29266S106 424 79,300 SH   DFND 1 0 79,300 0
ENDOLOGIX INC COM 29266S106 11,326 2,116,925 SH   SOLE 2,116,925 0 0
EXACT SCIENCES CORP COM 30063P105 42 200 SH Put DFND 1 0 200 0
EXACT SCIENCES CORP COM 30063P105 1,122 5,341 SH Put SOLE 5,341 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 82 13,627 SH   DFND 1 0 13,627 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 2,186 363,770 SH   SOLE 363,770 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 394 19,450 SH   DFND 1 0 19,450 0
HALOZYME THERAPEUTICS INC COM 40637H109 10,496 518,050 SH   SOLE 518,050 0 0
HEALTHSOUTH CORP COM NEW 421924309 208 4,200 SH   DFND 1 0 4,200 0
HEALTHSOUTH CORP COM NEW 421924309 5,539 112,100 SH   SOLE 112,100 0 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 1,603 614,022 SH   SOLE 614,022 0 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 60 23,000 SH   DFND 1 0 23,000 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 784 52,300 SH   DFND 1 0 52,300 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 20,934 1,396,500 SH   SOLE 1,396,500 0 0
MEDTRONIC PLC SHS G5960L103 404 5,000 SH   DFND 1 0 5,000 0
MEDTRONIC PLC SHS G5960L103 10,707 132,600 SH   SOLE 132,600 0 0
MIMEDX GROUP INC COM 602496101 332 26,300 SH   DFND 1 0 26,300 0
MIMEDX GROUP INC COM 602496101 8,827 700,000 SH   SOLE 700,000 0 0
MYLAN N V SHS EURO N59465109 927 21,900 SH   DFND 1 0 21,900 0
MYLAN N V SHS EURO N59465109 24,734 584,600 SH   SOLE 584,600 0 0
NOVARTIS A G SPONSORED ADR 66987V109 621 7,400 SH   DFND 1 0 7,400 0
NOVARTIS A G SPONSORED ADR 66987V109 16,582 197,500 SH   SOLE 197,500 0 0
NXSTAGE MEDICAL INC COM 67072V103 187 7,700 SH   DFND 1 0 7,700 0
NXSTAGE MEDICAL INC COM 67072V103 4,979 205,500 SH   SOLE 205,500 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 135 6,500 SH   DFND 1 0 6,500 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 3,609 173,500 SH   SOLE 173,500 0 0
REGENERON PHARMACEUTICALS COM 75886F107 41,130 109,400 SH   SOLE 109,400 0 0
REGENERON PHARMACEUTICALS COM 75886F107 1,541 4,100 SH   DFND 1 0 4,100 0
REVANCE THERAPEUTICS INC COM 761330109 304 8,500 SH   DFND 1 0 8,500 0
REVANCE THERAPEUTICS INC COM 761330109 8,146 227,855 SH   SOLE 227,855 0 0
SANOFI SPONSORED ADR 80105N105 1,552 36,100 SH   DFND 1 0 36,100 0
SANOFI SPONSORED ADR 80105N105 41,438 963,686 SH   SOLE 963,686 0 0
SELECT MED HLDGS CORP COM 81619Q105 312 17,700 SH   DFND 1 0 17,700 0
SELECT MED HLDGS CORP COM 81619Q105 8,345 472,800 SH   SOLE 472,800 0 0
SIENTRA INC COM 82621J105 246 17,500 SH   DFND 1 0 17,500 0
SIENTRA INC COM 82621J105 6,568 467,107 SH   SOLE 467,107 0 0
TG THERAPEUTICS INC COM 88322Q108 401 48,900 SH   DFND 1 0 48,900 0
TG THERAPEUTICS INC COM 88322Q108 10,711 1,306,278 SH   SOLE 1,306,278 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 4,619 165,600 SH   SOLE 165,600 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 173 6,200 SH   DFND 1 0 6,200 0