144 0001219927 XXXXXXXX LIVE 0001579428 Axsome Therapeutics, Inc. 001-37635 One World Trade Center 29th Floor New York NY 10007 1-212-332-3241 Herriot Tabuteau Officer Common Stock Goldman Sachs & Co. LLC 200 West Street New York NY 10282 50459 6808432.87 50412640 11/04/2025 NASD Common Stock 05/27/2016 Acquired as compensation -- Stock Options The Issuer N 50459 05/27/2016 Compensation -- Cashless exercise / same-day sale N Herriot Tabuteau One World Trade Center 29th Floor New York NY 10007 Common Stock 10/06/2025 19220 2309661.63 Herriot Tabuteau One World Trade Center 29th Floor New York NY 10007 Common Stock 11/03/2025 44613 11902021.33 Herriot Tabuteau One World Trade Center 29th Floor New York NY 10007 Common Stock 11/03/2025 47092 234586.66 Herriot Tabuteau One World Trade Center 29th Floor New York NY 10007 Common Stock 09/12/2025 27907 3319894.86 Herriot Tabuteau One World Trade Center 29th Floor New York NY 10007 Common Stock 09/15/2025 15254 1790378.76 Herriot Tabuteau One World Trade Center 29th Floor New York NY 10007 Common Stock 09/16/2025 19719 2251690.92 Herriot Tabuteau One World Trade Center 29th Floor New York NY 10007 Common Stock 10/07/2025 13390 1590307.54 Herriot Tabuteau One World Trade Center 29th Floor New York NY 10007 Common Stock 10/08/2025 12774 1518049.39 The sales of shares set forth herein are made in connection with a selling plan dated 6/13/2025, that is intended to comply with Rule 10b5-1(c). 11/04/2025 06/13/2025 Goldman Sachs & Co. LLC on behalf of Herriot Tabuteau