144 0001231615 XXXXXXXX LIVE 0001579428 Axsome Therapeutics, Inc. 001-37635 ONE WORLD TRADE CENTER, 29TH FLOOR NEW YORK NY 10007 (212) 332-3241 JEFFS ROGER Director Common Charles Schwab & Co., Inc.

3000 Schwab Way Westlake TX 76262

20000 2400658.00 49901487 08/26/2025 NASDAQ Common 05/27/2016 Exercise and Hold Axsome Therapeutics, Inc. N 1298 05/27/2016 Cash Common 03/15/2017 Exercise and Hold Axsome Therapeutics, Inc. N 18702 03/15/2017 Cash N ROGER JEFFS

ONE WORLD TRADE CENTER, 29TH FLOOR NEW YORK NY 10007

Axsome Therapeutics, Inc. 08/22/2025 16694 2004598.00 08/26/2025 02/26/2025 ROGER JEFFS