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The authorized amount under a common stock sales agreement.

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The gross sales during the period under a common stock sales agreement.

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Share based compensation arrangement by share based payment award equity instruments other than options cancelled in period.

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Net equity impact of the value of new stock issued during the period. Includes shares issued in an initial public offering or a secondary public offering.

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The per share exercise price of warrants

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The amount utilized for warrants.

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Exercise price per share or per unit of warrants or rights outstanding.

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Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Amount of cost to be recognized for nonvested award under share-based payment arrangement. Excludes share and unit options.

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Amount of cost to be recognized for option under share-based payment arrangement.

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The cash outflow for cost incurred directly with the issuance of an equity security.

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Period over which grantee's right to exercise award under share-based payment arrangement is no longer contingent on satisfaction of service or performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, combination of market, performance or service condition.

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Weighted average remaining contractual term for equity-based awards excluding options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Price of a single share of a number of saleable stocks of a company.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Number of non-vested options outstanding.

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Number of options vested.

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Number of new stock issued during the period.

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Equity impact of the value of new stock issued during the period. Includes shares issued in an initial public offering or a secondary public offering.

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Stockholders' Equity - Additional Information (Details)				1 Months Ended							12 Months Ended
Stockholders' Equity - Additional Information (Details)	Dec. 05, 2019 USD ($)	Oct. 01, 2018 USD ($)	Sep. 27, 2018 USD ($) $ / shares shares	Nov. 30, 2020 shares	Jun. 30, 2020 USD ($) shares	Dec. 31, 2019 USD ($) $ / shares shares	May 31, 2019 USD ($)	Jan. 31, 2019 USD ($) shares	Dec. 31, 2017 USD ($) $ / shares shares	Oct. 31, 2017 USD ($)	Dec. 31, 2020 USD ($) Vote $ / shares shares	Dec. 31, 2019 USD ($) $ / shares shares	Dec. 31, 2018 USD ($) $ / shares	Dec. 11, 2017 $ / shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued \| shares									1,783,587
Proceeds from issuance of common stock, gross									$ 9,500,000
Share Price \| $ / shares									$ 5.325
Exercise price of warrants (in dollars per share) \| $ / shares						$ 7.21			$ 5.21		$ 80.43	$ 7.21	$ 6.35
Proceeds from issuance of common stock, net									$ 8,800,000
Issuance costs									$ 745,856
Common stock, voting right per share \| Vote											1
Stock-based compensation expense											$ 14,756,206	$ 6,115,160	$ 1,754,974
Stock option to purchase shares of common stock cancelled \| shares											207,628
Weighted average grant date fair value \| $ / shares											$ 36.77	$ 12.49	$ 1.99
Unrecognized compensation cost related to non-vested stock options expected to be recognized											$ 20,900,000
Expected vesting period for non-vested share-based compensation											2 years 9 months 18 days
Non-vested options outstanding \| shares											10,716
Intrinsic value of stock options exercised						$ 4,500,000					$ 9,400,000	$ 4,500,000	$ 500,000
Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock option to purchase shares of common stock cancelled \| shares				38,267
Non-cash stock-based compensation expense related to plan cancelled											2,100,000
Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Non-cash stock-based compensation expense related to plan cancelled											$ 500,000
Stock option to purchase shares of common stock cancelled \| shares											11,735
Vesting period											4 years
Compensation cost not yet recognized related to unvested RSUs											$ 4,100,000
Weighted average contractual term											3 years 3 months 18 days
Director
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting of stock options \| shares					21,666
Stock-based compensation expense					$ 1,300,000
2013 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares available for future grant \| shares											0
2015 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares available for future grant \| shares											4,149,112
2018 Registered Direct Offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued \| shares			2,966,667
Proceeds from issuance of common stock, gross			$ 8,900,000
Share Price \| $ / shares			$ 3.00
Proceeds from issuance of common stock, net		$ 8,800,000
Underwritten Public Offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued \| shares						2,300,000
Proceeds from issuance of common stock, gross						$ 200,100,000
Share Price \| $ / shares						$ 87.00						$ 87.00
Proceeds from issuance of common stock, net						$ 187,100,000
2019 Shelf Registration
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Proceeds from issuance of common stock, gross	$ 221,900,000
Common warrants
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Price \| $ / shares									$ 5.60
Exercise price of warrants (in dollars per share) \| $ / shares									$ 5.25					$ 5.25
Issuance costs									$ 583,768
Common warrants \| 2016 Shelf Registration
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Exercise price \| $ / shares									$ 5.25
Warrant utilized									$ 9,400,000
Placement agent warrants
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued \| shares									107,015
Share Price \| $ / shares									$ 5.60
Exercise price of warrants (in dollars per share) \| $ / shares														$ 6.6562
Issuance costs									$ 81,000
Exercise price \| $ / shares									$ 6.6562
Placement agent warrants \| 2016 Shelf Registration
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Exercise price \| $ / shares									$ 6.6562
Warrant utilized									$ 712,313
SVB Leerink
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock sales agreement, gross sales								$ 25,800,000
Shares issued \| shares								3,164,015
Common stock sales agreement, commission percentage							3.00%	3.00%
Common stock sales agreement, shares unsold amount							$ 29,900,000
SVB Leerink \| December 2019 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued \| shares											167,243	89,390
Common stock sales agreement, commission percentage						3.00%						3.00%
Proceeds from issuance of common stock, gross											$ 14,600,000	$ 7,300,000
Proceeds from issuance of common stock, net											$ 14,100,000	$ 7,100,000
SVB Leerink \| Maximum [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock sales agreement, authorized amount							$ 50,000,000			$ 30,000,000
SVB Leerink \| Maximum [Member] \| December 2019 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock sales agreement, authorized amount						$ 80,000,000