Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statements:

· Registration Statement (Form S-8 No. 333-217002) pertaining to the Axsome Therapeutics, Inc. 2015 Omnibus Incentive Compensation Plan; 

· Registration Statement (Form S-8 No. 333-208579) pertaining to the Axsome Therapeutics, Inc. 2015 Omnibus Incentive Compensation Plan;

· Registration Statement (Form S-8 No. 333-230296) pertaining to the Axsome Therapeutics, Inc. 2015 Omnibus Incentive Compensation Plan;

· Registration Statement (Form S-8 No. 333-226824) pertaining to Axsome Therapeutics, Inc. 2015 Omnibus Incentive Compensation Plan; and

· Registration Statement (Form S-3ASR No. 333-235372) of Axsome Therapeutics, Inc. and in the related Prospectus;

of our report dated March 12, 2020, with respect to the consolidated financial statements of Axsome Therapeutics, Inc. included in this Annual Report (Form 10-K) of Axsome Therapeutics, Inc. for the year ended December 31, 2019.

	/s/ Ernst & Young LLP
New York, NY
March 12, 2020