<SEC-DOCUMENT>0001558370-19-011631-index.html : 20191220
<SEC-HEADER>0001558370-19-011631.hdr.sgml : 20191220
<ACCEPTANCE-DATETIME>20191219202333
ACCESSION NUMBER:		0001558370-19-011631
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20191220
DATE AS OF CHANGE:		20191219

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Axsome Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001579428
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				454241907
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-235372
		FILM NUMBER:		191297479

	BUSINESS ADDRESS:	
		STREET 1:		200 BROADWAY, 3RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10038
		BUSINESS PHONE:		(212) 332-3241

	MAIL ADDRESS:	
		STREET 1:		200 BROADWAY, 3RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10038
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>f424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: f424b5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>f424b5g001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: f424b5g001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>f424b5g002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: f424b5g002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>f424b5g003.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: f424b5g003.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>f424b5g004.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: f424b5g004.jpg

</DOCUMENT>
</SEC-DOCUMENT>