Consolidated Statements of Operations - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Operating expenses:
Research and development	$ 19,957,616	$ 21,199,860	$ 6,776,987
General and administrative	7,206,691	6,343,648	2,419,289
Total operating expenses	27,164,307	27,543,508	9,196,276
Loss from operations	(27,164,307)	(27,543,508)	(9,196,276)
Interest and amortization of debt discount/premium (expense) income	(1,340,199)	(132,424)	(736,048)
Tax credit	207,114	474,279
Change in fair value of warrant liability	(646,000)		(108,539)
Change in fair value of embedded derivative liabilities			274,800
Loss on extinguishment of debt			(2,444,516)
Net loss	$ (28,943,392)	$ (27,201,653)	$ (12,210,579)
Net loss per common share, basic and diluted	$ (1.27)	$ (1.42)	$ (1.02)
Weighted average common shares outstanding, basic and diluted	22,764,606	19,150,690	11,945,318