X0306 4 2023-03-02 0 0001579428 Axsome Therapeutics, Inc. AXSM 0001219927 TABUTEAU HERRIOT C/O AXSOME THERAPEUTICS, INC. 22 CORTLANDT STREET, 16TH FLOOR NEW YORK NY 10007 1 1 1 0 CHIEF EXECUTIVE OFFICER Employee Stock Option (Right to Buy) 65.32 2023-03-02 4 A 0 110032 0.00 A 2033-03-01 Common Stock 110032 110032 D Restricted Stock Units 2023-03-02 4 A 0 62400 0.00 A Common Stock 62400 62400 D The option will vest in substantially equal quarterly installments over four years such that the option will be fully vested on March 2, 2027. Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock. 25% of the RSUs will vest on the one (1) year anniversary of the date of grant. The remaining RSUs will vest in in three substantially equal annual installments, such that the RSUs will be fully vested on March 2, 2027. Vested shares will be delivered to the reporting person upon the earlier of (i) the closing of a Change in Control (as defined in the Issuer's Amended and Restated 2015 Omnibus Incentive Compensation Plan (the "Plan"), (ii) the reporting person's separation of service from the Issuer (including termination with or without Cause (as defined in the Plan), or termination due to death or disability), or (iii) seven (7) years from the date of grant. /s/ Herriot Tabuteau, M.D. 2023-03-06