X0306 4 2021-11-12 0 0001579428 Axsome Therapeutics, Inc. AXSM 0001742143 Pizzie Nick C/O AXSOME THERAPEUTICS, INC. 22 CORTLANDT STREET, 16TH FLOOR NEW YORK NY 10007 0 1 0 0 CHIEF FINANCIAL OFFICER Employee Stock Option (Right to Buy) 39.26 2021-11-12 4 A 0 36086 0.00 A 2031-11-11 Common Stock 36086 36086 D The option will start to vest one year from November 12, 2021 and then will vest in substantially equal quarterly installments over three years such that the option will be fully vested on November 12, 2025. /s/ Nick Pizzie 2021-11-15