X0306 4 2021-05-12 0 0001579428 Axsome Therapeutics, Inc. AXSM 0001658379 Coleman Mark C/O AXSOME THERAPEUTICS, INC. 22 CORTLANDT STREET, 16TH FLOOR NEW YORK NY 10007 1 0 0 0 Common Stock 2021-05-12 4 P 0 500 58.15 A 420998 I See Footnote Common Stock 4100 D Such shares were purchased by an entity, of which the reporting person has voting and dispositive power, and therefore, the reporting person is deemed to be the indirect beneficial owner of such shares. Represents additional shares held directly by the reporting person prior to May 12, 2021. /s/ Mark Coleman 2021-05-13