X0306 4 2019-09-26 0 0001579428 Axsome Therapeutics, Inc. AXSM 0001742143 Pizzie Nick C/O AXSOME THERAPEUTICS, INC. 200 BROADWAY, 3RD FLOOR NEW YORK NY 10038 0 1 0 0 Chief Financial Officer Common Stock 2019-09-26 4 P 0 2180 24.80 A 40440 D Common Stock 60 I By UTMA account 2,000 shares were purchased by the Reporting Person's Roth IRA and 180 shares were purchased by the Reporting Person's IRA. Represents 60 shares of common stock indirectly held by the reporting person as custodian for his son's UTMA account. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. /s/ Nick Pizzie 2019-09-30