Stockholders' Equity - Additional Information (Details)	1 Months Ended					12 Months Ended
	Jul. 31, 2023 USD ($) $ / shares shares	Dec. 31, 2022 USD ($)	Aug. 31, 2022 USD ($)	Mar. 31, 2022 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2023 USD ($) Vote $ / shares shares	Dec. 31, 2022 USD ($) $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected cash dividend						$ 0
Expense						62,620	$ 37,726	$ 20,801
Stock-based compensation expense capitalized						2,700,000	1,300,000
Proceeds from Issuance of Common Stock						$ 258,750,000	$ 243,763,000	$ 7,436,000
Common stock, voting right per share | Vote						1
Weighted average grant date fair value | $ / shares						$ 53.07	$ 28.18	$ 39.64
Unrecognized compensation cost related to non-vested stock options expected to be recognized						$ 162,000,000
Expected vesting period for non-vested share-based compensation						2 years 9 months 18 days
Non-vested options outstanding | shares						6,169
Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of common stock | shares						3,450,000	5,320,460	110,296
Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period						4 years
Compensation cost not yet recognized related to unvested RSUs						$ 25,900,000
Weighted average contractual term						2 years 6 months
Intrinsic value lapsed		$ 1,500,000				$ 4,900,000	$ 1,500,000	$ 400,000
2015 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares available for future grant | shares						2,168,858
June 2023 Public Offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Proceeds from Issuance of Common Stock	$ 31,700,000					$ 211,300,000
Underwriting discounts and commissions	$ 2,000,000					13,500,000
Other offering costs						$ 200,000
June 2023 Public Offering | Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Price | $ / shares	$ 75					$ 75
Issuance of common stock | shares	450,000					3,000,000
Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Purchase price of common stock percent						85.00%
Expense						$ 1,100,000
Employee Stock Purchase Plan | Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued | shares						0
Leerink | December 2019 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Proceeds from issuance of common stock, gross								$ 7,400,000
Shares issued | shares								110,296
Proceeds from issuance of common stock, net								$ 7,200,000
Common stock sales agreement, commission percentage				3.00%
Leerink | December 2019 and March 2022 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Proceeds from issuance of common stock, gross							$ 238,800,000
Shares issued | shares							5,167,973
Proceeds from issuance of common stock, net							$ 231,800,000
Leerink | March 2022 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock sales agreement, authorized amount		$ 250,000,000
Proceeds from Issuance of Common Stock						$ 0
Maximum | Leerink | December 2019 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock sales agreement, authorized amount					$ 80,000,000
Maximum | Leerink | March 2022 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock sales agreement, authorized amount			$ 250,000,000	$ 200,000,000
Common stock sales agreement, commission percentage			3.00%	3.00%
Hercules Capital Inc | March 2022 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued | shares						152,487
Proceeds from issuance of common stock, net						$ 5,000,000
Share Price | $ / shares						$ 32.79