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Stockholders' Equity - Additional Information (Details)
1 Months Ended 3 Months Ended 6 Months Ended
Jul. 31, 2023
USD ($)
$ / shares
shares
Dec. 31, 2022
USD ($)
$ / shares
Aug. 31, 2022
USD ($)
Mar. 31, 2022
USD ($)
Dec. 31, 2019
USD ($)
Jun. 30, 2023
USD ($)
$ / shares
shares
Jun. 30, 2022
USD ($)
shares
Mar. 31, 2022
shares
Jun. 30, 2023
USD ($)
Days
Vote
$ / shares
shares
Jun. 30, 2022
USD ($)
Dec. 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Expected cash dividend                 $ 0    
Expense           $ 15,922 $ 10,162   28,865 $ 17,760  
Proceeds from Issuance of Common Stock                 $ 225,000,000 $ 63,560,000  
Common stock, voting right per share | Vote                 1    
Weighted average grant date fair value | $ / shares                 $ 52.18    
Unrecognized compensation cost related to non-vested stock options expected to be recognized           $ 153,300,000     $ 153,300,000    
Expected vesting period for non-vested share-based compensation                 3 years    
Non-vested options outstanding | shares           6,169     6,169    
Exercise price of warrants (in dollars per share) | $ / shares   $ 46.75       $ 56.80     $ 56.80    
Common Stock                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Issuance of common stock | shares           3,000,000 1,023,153 1,044,081      
Warrants | 2020 warrants                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Common stock to be issued if warrants are exercised (in shares) | shares           15,541     15,541    
Exercise price of warrants (in dollars per share) | $ / shares           $ 80.43     $ 80.43    
Trading days | Days                 10    
Term of warrants (in years)                 7 years    
Fair value           $ 900,000     $ 900,000    
Warrants | 2022 warrants                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Common stock to be issued if warrants are exercised (in shares) | shares           35,255     35,255    
Exercise price of warrants (in dollars per share) | $ / shares           $ 31.91     $ 31.91    
Fair value           $ 800,000     $ 800,000    
Warrants | 2023 Warrants                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Common stock to be issued if warrants are exercised (in shares) | shares           9,700     9,700    
Exercise price of warrants (in dollars per share) | $ / shares           $ 77.31     $ 77.31    
Fair value           $ 1,600,000     $ 1,600,000    
Restricted Stock Units                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Vesting period                 4 years    
Compensation cost not yet recognized related to unvested RSUs           $ 27,400,000     $ 27,400,000    
Weighted average contractual term                 2 years 10 months 24 days    
2015 Plan                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Shares available for future grant | shares           2,916,940     2,916,940    
June 2023 Public Offering                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Proceeds from Issuance of Common Stock $ 31,700,000               $ 211,300,000    
Underwriting discounts and commissions $ 2,000,000.0         $ 13,500,000     13,500,000    
Other offering costs                 $ 200,000    
June 2023 Public Offering | Common Stock                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Share Price | $ / shares $ 75.00         $ 75.00     $ 75.00    
Issuance of common stock | shares 450,000               3,000,000.0    
Employee Stock Purchase Plan                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Purchase price of common stock percent                 85.00%    
Expense           $ 200,000     $ 200,000    
Employee Stock Purchase Plan | Common Stock                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Shares issued | shares           0     0    
Leerink | December 2019 Sales Agreement                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Common stock sales agreement, commission percentage                     3.00%
Leerink | March 2022 Sales Agreement                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Common stock sales agreement, authorized amount   $ 250,000,000                  
Maximum | Leerink | December 2019 Sales Agreement                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Common stock sales agreement, authorized amount         $ 80,000,000            
Maximum | Leerink | March 2022 Sales Agreement                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Common stock sales agreement, authorized amount     $ 250,000,000 $ 200,000,000              
Common stock sales agreement, commission percentage     3.00% 3.00%       3.00%      
Hercules Capital Inc | Warrants | Third Amendment To Loan and Security Agreement                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Common stock to be issued if warrants are exercised (in shares) | shares           18,724     18,724    
Exercise price of warrants (in dollars per share) | $ / shares           $ 55.01     $ 55.01